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在更年期过渡期间肺功能的变化:对年度检查的纵向分析
Ryosuke Imai1, Shosei Ro2, Ann-Marcia C Tukpah3
1Department of Pulmonary Medicine, Thoracic Center Tokyo, Japan; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Chest
|September 21, 2025
概括
肺功能,特别是FVC (强迫生命能力),在更年期前5年开始显著下降,并在更年期后继续下降. 在这个更年期过渡期间,FEV1 (1秒内强制呼气体积) 的变化不那么明显.
科学领域:
- 肺部医学 肺部医学
- 妇女健康 妇女健康
- 生殖内分泌学 生殖内分泌学
背景情况:
- 在更年期过渡期间的肺功能轨迹尚不清楚.
- 调查像FVC和FEV1这样的肺功能标志物的变化对于中年妇女的健康至关重要.
研究的目的:
- 确定FVC和FEV1轨迹在更年期过渡期间如何变化.
- 为了比较FVC和FEV1在绝经前期和绝经后期的下降率.
主要方法:
- 追溯队列研究分析了来自健康检查数据库的5554名女性 (2004-2020年).
- 绝经状态分为绝经前期,绝经前期和绝经后期,使用数据驱动方法.
- 使用中断时间序列和混合效应模型估计的FVC和FEV1的年度变化率.
主要成果:
- FVC下降的速度在更年期前5年加速,在更年期后持续 (分别为-17.5毫升/年和-18.8毫升/年的额外下降).
- 与绝经前的比率相比,FEV1在绝经前期 (-1.5毫升/年) 和绝经后 (-0.4毫升/年) 期间呈现较小,不那么显著的下降.
- 更年期的中位数年龄为52岁,平均随访时间为11年.
结论:
- 更年期状态与中年妇女的加速FVC下降显著相关,在最后的月经周期前几年开始.
- 虽然FVC的下降显著增加,但更年期过渡期间FEV1的变化很小.
- 这些发现突显了荷尔蒙变化对中年期肺功能,特别是FVC的影响.
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