癌症中的微生物三级淋巴体结构的形成
Hao Li1, Fei-Yang Chen2, Qing Wang1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430079, China; Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Seminars in cancer biology
|September 21, 2025
概括
三级淋巴体结构 (TLS) 对于癌症免疫疗法至关重要,增强免疫检查点阻塞 (ICB) 的有效性. 微生物影响TLS的形成,为癌症治疗提供潜在的新生物标志物和治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 微生物学 微生物学
背景情况:
- 三级淋巴体结构 (TLS) 是瘤微环境 (TME) 的关键组成部分,可显著提高免疫检查点阻塞 (ICB) 治疗的有效性.
- 在各种癌症中,TLS的存在是ICB治疗反应的强有力的预测生物标志物.
- 新出现的证据强调了多种微生物 (细菌,病毒,真菌) 在调节ICB治疗结果中的作用.
研究的目的:
- 本综述旨在阐明微生物与TME内的TLS形成之间的复杂关系.
- 它重点关注涉及TLS发展的信号通路,以及微生物相互作用如何影响这些通路.
- 该审查旨在根据这些微生物-TLS相互作用确定潜在的诊断和治疗点.
主要方法:
- 本综述综合了当前关于TLS形成机制的研究,包括关键信号通路.
- 它分析了调查各种微生物对TLS发展的影响的研究.
- 这篇评论讨论了微生物如何影响TLS形成的背景下,化学激素,抗原呈现和免疫细胞功能.
主要成果:
- 微生物通过影响关键信号通路,在促进TLS形成方面发挥着重要作用.
- 特定的微生物物种可以调节TME,影响免疫细胞透和TLS发育所需的功能.
- 这些微生物驱动的TLS变化与ICB治疗的改变反应有关.
结论:
- 了解微生物影响TLS形成的机制对于推进癌症免疫治疗至关重要.
- 参与TLS发展的微生物,化学因子和信号通路代表了预测ICB疗效的有希望的生物标志物.
- 针对微生物-TLS相互作用可能会导致新的治疗策略,以改善癌症治疗结果.
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