新型β-lactamase抑制剂与cefepime:它们在临床实践中的位置?
Sunish Shah1,2, Sahil Angelo2,3, Brandon J Smith2,3
1Department of Pharmacy, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Expert opinion on pharmacotherapy
|September 21, 2025
概括
新型β-乳酸酶抑制剂恩米塔扎巴克坦,塔尼博巴克坦和齐德巴克坦与塞菲皮姆结合,对抗抗菌素耐药性. 塞费皮姆-齐德巴克坦对具有挑战性的格拉姆阴性病原体具有前景,但对所有药物需要更多的临床数据.
科学领域:
- 抗微生物耐药性 抗微生物耐药性
- 药理学 药理学是指药理学的学科.
- 传染病 传染病 传染病
背景情况:
- 新型β-乳酸酶抑制剂 (enmetazobactam,taniborbactam,zidebactam) 与cefepime结合使用,以解决抗菌素耐药性的问题.
- 现有的治疗选择面临来自常见和新兴耐药机制的挑战.
研究的目的:
- 审查和总结在体外,动物和临床数据的cefepime-enmetazobactam,cefepime-taniborbactam和cefepime-zidebactam.
- 预测这些新型抗生素组合的潜在临床作用.
主要方法:
- 关于 MEDLINE,PubMed 和 EMBASE 的英语文章的文献评论.
- 搜索术语包括"Cefepime-enmetazobactam"",cefepime-taniborbactam"和"Cefepime-zidebactam" (2015年1月至2025年5月).这些搜索术语包括"Cefepime-enmetazobactam"",cefepime-taniborbactam"和"Cefepime-zidebactam" (2015年1月至2025年5月).这些搜索术语包括"Cefepime-enmetazobactam"和"Cefepime-zidebactam" (2015年1月至2025年5月).
主要成果:
- 塞费皮姆-enmetazobactam和塞费皮姆-taniborbactam显示在体外活动重叠当前选项.
- 塞费皮姆-齐德巴克坦在体外对具有挑战性的格拉姆阴性病原体具有显著的活性,包括金属β-乳糖酶生产者.
- 对所有组合的临床数据有限.
结论:
- 塞费皮姆-齐德巴克坦可能会填补难以治疗的格拉姆阴性感染的关键缺口.
- 进一步的临床数据和现实世界的证据对于定义治疗利基,耐药性选择潜力和这些药物的比较益处至关重要.
相关概念视频
01:22Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
179
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
179
01:27Combined Effects of Drugs: Synergism
6.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
6.8K
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
321
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
321
01:26Urine Studies II: Urine Culture and Sensitivity Test
879
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
879
01:30Development of Antibiotic Resistance
1.3K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.3K
00:57Antibiotic Selection
59.4K
Overview
59.4K