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Updated: Jan 17, 2026

Evaluation of Exon Inclusion Induced by Splice Switching Antisense Oligonucleotides in SMA Patient Fibroblasts
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合成,生物活动和分子动力学模拟LNA-电荷中性链接用于增强的拼接切换反意义寡核酸

Alice Kennett1, Lillian Lie1, Martin Flerin1

  • 1Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.

Angewandte Chemie (International ed. in English)
|September 22, 2025
PubMed
概括

研究人员探索了对反感性寡核酸 (ASO) 的新型化学修饰,以改善治疗性质. 这种LNA-硫酸盐骨干显得有前途,为潜在的药物开发提供了稳定的双重组形成和良好的细胞活性.

关键词:
这是一种反意义的寡核酸.体操活动体操活动.锁定核酸的核酸被锁定.中性链接是中性链接.拼接切换 连接切换

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