黄素与皮质类固醇治疗症状性口腔平坦:系统性审查和元分析
Sadeq A Al-Maweri1, Gamilah Al-Qadhi2, Ahmed Yaseen Alqutaibi3
1College of Dental Medicine, QU Health, Qatar University, Doha, Qatar.
Clinical and experimental dental research
|September 22, 2025
概括
与皮质类固醇相比,黄素对治疗口腔平坦 (OLP) 有望,在一周内有效减少疼痛. 由于研究的局限性,需要进一步的研究.
科学领域:
- 口腔医学是指口腔医学.
- 药理学 药理学是指药理学的学科.
- 基于证据的牙科.
背景情况:
- 口腔平坦 (OLP) 提出了管理挑战,没有明确的治疗方法.
- 对OLP的新型治疗剂的研究至关重要.
研究的目的:
- 系统地审查和元分析黄素在管理OLP中的疗效.
- 为了比较黄素的有效性与标准治疗,如皮质类固醇.
主要方法:
- 在主要数据库 (PubMed,Scopus,Web of Science,Google Scholar) 进行了全面的文献搜索,截至2025年3月31日.
- 包括随机对照试验,比较黄素与OLP治疗的皮质类固醇.
- 对具有可量化的数据的研究进行了元分析.
主要成果:
- 审查了11项涉及499名患者的试验;其中9项被纳入了元分析.
- 与皮质类固醇 (SMD, -0.70; p=0.03) 相比,黄素在一周内显示出明显优异的疼痛减轻作用 (SMD, -0.70; p=0.03).
- 在较晚的随访点 (2,4,12周) 中,没有发现疼痛减轻或临床病变改善的显著差异.
结论:
- 黄素在OLP症状管理方面表现出有前途的潜力.
- 限制包括显著的异质性和现有研究中偏差的高风险.
- 需要高质量,精心设计的试验,并进行长期随访,以确认疗效.
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