在正常FEV1z-score的控制良好的喘儿童中,亚临床小呼吸道功能障碍
Gökçen Kartal Öztürk1, Hazal Gacemer1, Ece Halis1
1Department of Pediatric Pulmonology, Ege University Faculty of Medicine, Izmir, Turkey.
概括
亚临床的小呼吸道功能障碍 (SAD) 可能会影响患有控制良好的喘的儿童. 脉冲振荡计系统 (IOS) 能够有效地检测SAD,而较年轻的亚托皮儿童的风险更高.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 喘研究 喘研究
背景情况:
- 亚临床小呼吸道功能障碍 (SAD) 与喘持久性,控制不良和恶化有关.
- 评估SAD在控制良好的儿科喘和正常的螺旋测量是至关重要的.
研究的目的:
- 通过脉冲振荡计系统 (IOS) 对患有控制良好的喘的儿童进行亚临床SAD评估.
- 为了确定肺功能测试 (PFT) 参数预测SAD.
- 为了确定与SAD相关的风险因素.
主要方法:
- 追溯队列研究将194名喘儿童 (6-18岁) 与正常FEV1z分数的151名健康对照人进行比较.
- 评估的螺旋计和IOS参数.
- 使用后勤回归和ROC曲线分析来预测PFT参数.
主要成果:
- 喘儿童的FEV1/FVC和FEF25-75较低,并且IOS参数发生变化 (较高的R5,R10,Fres,Ax,ΔR5-20;更负的X5-X20),尽管螺旋测量正常.
- ΔR5-20中度预测的SAD (OR 1.086,p<0.01) 的截止值为≥22.15% (AUC 0.660).
- 年轻的年龄和亚托皮是较高的ΔR5-20的独立风险因素.
结论:
- 亚临床SAD可能存在于患有控制良好的喘和正常FEV1.1的儿童中.
- IOS,特别是ΔR5-20,是用于SAD检测的敏感,独立于努力的工具.
- 建议对儿科喘进行常规的IOS评估,特别是在年轻的亚托皮性个体中.
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