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Updated: Jan 17, 2026

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老年人营养风险指数对术后认知功能障碍和在全身麻醉下进行关节整形术后并发症的影响:一项回顾性研究

Xia Li1, Yunyun Sun1, Liang Chen1

  • 1Department of Anesthesiology, The Second People's Hospital of Hefei, Hefei Hospital affiliated to Anhui Medical University, Hefei, China.

Rejuvenation research
|September 22, 2025
PubMed
概括

老年营养风险指数 (GNRI) 有效地预测了老年关节整形患者的术后认知功能障碍 (POCD) 和并发症. 较高的GNRI分数表明风险较低,强调其保护作用.

关键词:
老年人的营养风险指数发生并发症,并发症.年长的病人,老年患者.部关节整形术 部关节整形术术后认知功能障碍 术后认知功能障碍

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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