在中检测到抗生素耐药性基因:来自Cladonia stellaris的见解
Marta Alonso-García1,2,3, Paul B L George4,5, Samantha Leclerc4,5
1Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec G1V 0A6, Canada.
Annals of botany
|September 22, 2025
概括
抗生素耐药性基因 (ARG) 在偏远的北方鱼Cladonia stellaris中被发现,表明它们即使在人类影响最小的环境中也存在. 需要进一步的研究来了解这些基因在自然界的起源和传播.
科学领域:
- 环境微生物学环境微生物学
- 抗生素耐药性的生态学
背景情况:
- 抗生素耐药性基因 (ARG) 是日益增长的全球健康威胁,主要记录在人类影响的环境中.
- 它们在偏远的生态系统 (如北极森林) 的存在和起源尚不清楚.
研究的目的:
- 调查北极鱼Cladonia stellaris中ARG的发生,多样性和潜在起源.
- 评估度对ARG分布在这个偏远生态系统的影响.
主要方法:
- 分析了来自加拿大北部和南部树林的42个C. stellaris样本.
- 高通量定量PCR用于选33个ARG和3个移动遗传元素 (MGE).
- 16S rRNA基因测序用于细菌群体的表征和地理模式的统计分析.
主要成果:
- 在C. stellaris中检测到10个ARG和1个MGE.
- 特定的ARG (blaCTX-M-1,qnrB,qepA) 非常普遍,qepA超过16SrRNA基因丰度.
- 度显著影响了ARG概况,但细菌社区的组成没有.
结论:
- 在偏远的北极生态系统中,C. stellaris拥有多样化的ARG,这表明环境传播范围比以前想象的更广.
- 潜在的来源包括通过生物气溶的长途传播或菌体微生物群内的内源性发展.
- 需要使用先进技术进行进一步的研究,以阐明ARG生态和自然息地的演变.
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