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在直肠癌中进行局部切除:何时以及为谁?

Semra Demirli Atici^1,2, Aras Emre Canda^1,3, Mustafa Cem Terzi^1,3

¹Department of General Surgery, Acibadem Kent Hospital, Izmir 35620, Türkiye.

World journal of gastrointestinal oncology

|September 22, 2025

概括

局部切除 (LE) 提供了与直肠癌全腹腔切除 (TME) 相似的瘤结果,改善了生活质量. 需要进一步的研究来澄清长期结果,并指导治疗指南.

科学领域:

在瘤学瘤学.
外科胃肠道外科手术
临床研究临床研究

背景情况:

局部切除 (LE) 是一种可行的直肠癌治疗方法,可以在新辅助化疗或放射治疗后使用.
LE提供了与全腹腔切除术 (TME) 相似的瘤结果.
与TME相比,LE提高了生活质量 (QoL),并保持了功能.

研究的目的:

评估LE与TME对直肠癌的瘤和QOL结果.
为了解决关于LE的长期术后结果的不确定性.
为结直肠癌治疗提供基于证据的指导方针.

主要方法:

未来的随机对照试验 (RCT) 是为了比较而提出的.
长期跟踪对于评估瘤学结果至关重要.
在LE和TME之间对瘤结果和QoL进行比较分析.

主要成果:

在新辅助化疗或放射治疗后,LE显示出显著的瘤回归.
对于LE,其瘤治疗结果与TME相似.
LE与改善的功能结果和QOL有关.

结论:

乳腺癌是一种有效的直肠癌治疗选择,特别是在新辅助疗法后.
进一步的长期RCT对于巩固LE的作用和减少不确定性至关重要.
可以制定基于证据的指导方针,以优化直肠癌管理.

关键词:

当地切除术 (Local excision) 是一种切除术.低前切除综合征的前部切除综合征.新辅助性化疗或放射治疗.生活质量生活的质量.这是直肠癌.总体中肠直肠切除术.通过门进行内镜微手术.通过门进行的微创手术.

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