纤维细胞生长因子19-纤维细胞生长因子受体4轴:从瘤发生到高级肝细胞癌的向免疫治疗
Tian-Ao Zhan1, Feng Xia1, Hong-Wei Huang1
1Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.
World journal of gastrointestinal oncology
|September 22, 2025
概括
肝细胞癌 (HCC) 治疗正在通过向疗法推进. 纤维细胞生长因子19 (FGF19) -纤维细胞生长因子受体4 (FGFR4) 抑制剂显示出有希望的结果,特别是当与其他治疗结合使用时,可以获得更好的结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肝细胞癌 (HCC) 是一个主要的全球癌症负担,具有有限的先进阶段治疗方法.
- 纤维细胞生长因子19 (FGF19) -纤维细胞生长因子受体4 (FGFR4) 途径与HCC瘤发生和免疫治疗耐药性有关.
- 过度表达FGF19可以增加编程细胞死亡连接体1,影响瘤微环境.
研究的目的:
- 系统地审查关于FGFR4抑制剂在HCC治疗中的文献.
- 为了合成FGFR4抑制剂和向免疫治疗之间的组合策略.
- 探索FGF19作为HCC精密治疗的预测生物标志物.
主要方法:
- 使用PubMed和其他数据库进行系统的文献审查.
- 搜索术语包括"HCC"",FGF19"",FGFR4"",FGFR4抑制剂"",向治疗"",多酶抑制剂"",免疫疗法"",免疫检查点抑制剂"和"生物标志物".
- 对组合疗法的机制和临床证据的分析.
主要成果:
- 选择性FGFR4抑制剂在HCC治疗中显示出有效性.
- 组合疗法 (FGFR4抑制剂与MKI或免疫检查点抑制剂) 增强抗瘤效果.
- 伊尔帕格拉提尼布 (ABSK-011) 的客观应答率为43.5%,在阿特佐利祖马布治疗中增加到55.6%.
结论:
- FGFR4 抑制剂代表了对HCC的有希望的向治疗.
- 涉及FGFR4抑制剂和免疫治疗的组合策略提供了增强的治疗潜力.
- FGF19可以作为一个有价值的预测生物标志物来指导HCC治疗决策.
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