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新型USP18突变导致对JAK抑制剂有反应的严重干扰症

Xiangwei Sun1,2, Ming Li3, Yiying Dou1,2

  • 1Liangzhu Laboratory, Zhejiang University, Hangzhou, China.

Frontiers in immunology
|September 22, 2025
PubMed
概括

在USP18的新突变通过破坏I型干扰素 (IFN) 信号传递引起严重的全身炎症. 这项研究确定了新的USP18变体,并证明了xukolitinib.

关键词:
USP18 美元自发炎症是一种自发炎症.有针对性的治疗.这是一种I型干扰子.第一种类型的干扰异位病.

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