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介质干细胞和免疫微环境在旋转手套肌至骨治愈中的相互作用:目前的进展和未来的方向

Dong Li¹, Yujia Zou¹, Yuanting Zhao¹

¹Day Surgery Center, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an, China.

Frontiers in immunology

|September 22, 2025

概括

介酶干细胞 (MSCs) 通过调节免疫微环境来增强旋转的修复. 了解MSC-免疫细胞相互作用对于改善肌至骨的愈合和开发个性化的再生疗法至关重要.

科学领域:

再生医学是一种再生医学.
免疫学免疫学免疫学
整形外科手术整形外科手术

背景情况:

旋转手套的伤害往往导致肌到骨的愈合不佳,这是由于体再生失败和免疫失调造成的.
介酶干细胞 (MSCs) 由于它们的分化和免疫调节能力,显示出旋转修复的治疗潜力.

研究的目的:

审查MSC介导的肌到骨愈合的机制,重点是免疫调节.
讨论基于MSC的旋转手腕损伤再生疗法的当前进展和未来方向.

主要方法:

对MSCs,免疫细胞和旋转手套愈合的现有文献的审查.
分析无细胞方法,生物材料输送系统和免疫环境增强策略.
探索挑战和未来方向,包括人工智能驱动的个性化疗法.

主要成果:

MSCs与免疫细胞 (巨细胞,T细胞,NK细胞) 双向相互作用,影响愈合结果.
目前正在开发各种策略,如无细胞疗法和生物材料,以优化MSC功能.
人工智能与患者免疫简介的整合为个性化治疗分层提供了潜在的潜力.

结论:

利用MSC-免疫相互作用是推动旋转手套修复的关键.
个性化免疫调节疗法和先进的预测模型是有希望的未来方向.
解决MSC异质性和转化障碍对于临床成功至关重要.

关键词:

免疫微观环境免疫微环境免疫调节免疫调节免疫调节介质细胞干细胞介质细胞干细胞旋转器袖口撕裂的情况肌到骨的愈合方式组织再生组织再生

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