肠道屏障功能作为消化器外科手术患者炎症和营养状况的关键决定因素:现实研究
Jingjing Wang1, Jing Yan2, Linlin Shi1
1Department of Nutrition, The Third Central Hospital of Tianjin, National Medical Quality Control Center of Clinical Nutrition, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Tianjin, China.
消化器外科手术通常会损害肠道屏障,导致炎症和营养不良. 早期的肠道营养可以改善屏障功能,但延迟干预可能会阻碍恢复.
科学领域:
- 胃肠病学 胃肠病学
- 外科手术的结果
- 营养科学 营养科学
背景情况:
- 肠道屏障的完整性对健康至关重要,并且在消化器外科手术后经常受到损害.
- 肠道屏障功能受损与炎症和营养状况不佳有关.
研究的目的:
- 研究肠壁障碍对术后患者炎症和营养状况的影响.
- 评估这些患者营养治疗的必要性和有效性.
主要方法:
- 在745名手术和394名非手术患者中使用血清生物标志物评估肠道屏障完整性:二胺氧化酶 (DAO),D-乳酸盐 (D-lac) 和脂多糖化物 (LPS).
- 与炎症标志物和营养状况相关的屏障完整性;在营养治疗一周后分析生物标志物变化.
主要成果:
- 手术后肠道屏障损伤的高发病率,严重病例中DAO,D-lac和LPS升高.
- 肠道屏障受损与营养状况恶化和系统性炎症增加相关.
- 一周的营养干预,特别是早期肠道营养 (EEN),改善了屏障功能和减少了生物标志物,但纠正不足导致了糟糕的结果.
结论:
- 肠道屏障障碍是一种严重的术后并发症,导致炎症和营养不良.
- 早期肠道营养有助于恢复肠道屏障功能.
- 及时和适当的营养干预对于与消化器外科手术相关的肠道屏障功能障碍患者的成功治疗结果至关重要.
相关概念视频
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Physiology of Enteric Nervous System and Gut Health
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...


