器官芯片技术在癌症治疗中的应用和发展
Ling Xiao Wang1, Shu Ling Liu2, Ning Wu3
1School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, China.
Frontiers in oncology
|September 22, 2025
概括
器官芯片技术创建先进的3D癌症模型,改善药物查和个性化瘤学. 这个创新的平台克服了传统方法的局限性,为更有效的癌症治疗铺平了道路.
科学领域:
- 生物技术是生物技术.
- 癌症研究 癌症研究
- 微流体学 微流体学
背景情况:
- 癌症治疗受到瘤异质性,复杂的瘤微环境 (TME) 和治疗耐药性的阻碍.
- 传统的二维细胞培养缺乏足够的生理复杂性来准确地建模瘤.
- 有机器人芯片 (OoC) 技术通过整合微流体和组织工程来提供解决方案.
研究的目的:
- 突出 Organoid-on-a-Chip (OoC) 技术在癌症研究中的进步和潜力.
- 为了证明OOC能够创造生理上准确的3D瘤模型的能力.
- 讨论OOC对药物查,毒性测试和个性化瘤学的影响.
主要方法:
- 开发OOC平台,整合微流体学,组织工程和细胞生物学.
- 使用患者衍生器官 (PDO) 保持父母瘤的特征.
- 将血管化和多器官相互作用纳入OoC模型.
主要成果:
- OoC技术成功模拟了TME动态,包括血管化和多器官相互作用.
- 在结直肠癌模型中,患者衍生器官显示高药物反应准确率 (>87%).
- 血管化的瘤芯片可以研究血管生成动力学和药物疗效.
结论:
- 对癌症研究的传统模型来说,OOC技术是一个显著的进步.
- OoC平台对于药物查,毒性测试和推进个性化癌症治疗至关重要.
- 需要进一步发展多器官整合和政策调整,才能充分发挥OOC在取代动物模型和增强精准医学方面的潜力.
相关概念视频
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.