混合治疗剂用于通过传染性微环境调制的自我氧化伤口治疗
Taoyan Guo1,2,3, Fei Yan1, Jun Liu2
1Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang 261053, Shandong, P.R. China.
iScience
|September 22, 2025
概括
研究人员使用MOF@COF异构结构开发了一种新型的人工酶,用于治疗感染. 这种生物相容材料通过将过氧化转化为杀菌剂来增强抗菌疗法,并改善光动力疗法,加速伤口愈合.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 催化剂是一种催化剂.
背景情况:
- 人工酶提供治疗潜力,但面临合成和性能挑战.
- 层次的MOF@COF异构结构为人工酶设计提供了一种新的方法.
研究的目的:
- 开发一个模块化组装策略,用于创建分层的MOF@COF异构结构.
- 整合MOF和COF功能,以增强抗微生物和治疗效果.
主要方法:
- 通过共价接口工程,对层次的MOF@COF异构结构进行模块化组装.
- 在氨基功能化Fe-MIL-88A MOF核心上培育基于氨酸的COF外.
- 核心外架构和异质连接的表征.
主要成果:
- 实现了形态控制的核心外MOF@COF架构,具有定义的异质连接.
- 混合材料表现出双重MOF过氧化酶/酶类活性和COF光活性.
- MOF@COF将H2O2转化为杀菌性OH和O2,增强光动力学疗法并减轻缺氧.
- 证明了广泛的抗微生物活性和加速伤口愈合.
结论:
- MOF@COF异构结构代表了具有协同催化位点的生物相容人工酶的合理设计.
- 这种方法推进了感染治疗的自我强化治疗策略.
- 模块化组件绕过了复杂的单体合成,并放大了功能.
相关概念视频
Oxygen Requirements and Growth Patterns
1.2K
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
1.2K
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
1.9K
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
1.9K
Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
589
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
589
Hand hygiene
5.6K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
5.6K
Chemical Agents for Microbial Control
763
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
763


