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Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
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Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration
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通过低维护剂量协议,可以有效和安全地实现卵子脱敏.

Diana Toscano-Rivero1, Nofar Kimchi2, Wei Zhao1

  • 1Division of Experimental Medicine, Department of Medicine, McGill University and the Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada.

The journal of allergy and clinical immunology. Global
|September 22, 2025
PubMed
概括

300毫克的低剂量卵口服免疫疗法 (E-OIT) 是安全有效的,可以使患有蛋过敏的儿童变得不敏感. 这种方法显著增加了耐受性卵子剂量,副作用最小,提供了一个有前途的治疗选择.

关键词:
在 DBPCFCFC 中,我们可以食物过敏 食物过敏过敏反应过敏反应蛋过敏 过敏对蛋的过敏低剂量的低剂量口服食物挑战口服食物挑战口服免疫疗法是口服免疫疗法.皮肤刺伤测试 皮肤刺伤测试

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科学领域:

  • 过敏和免疫学 过敏和免疫学
  • 儿科医学 儿科医学
  • 食品科学 食品科学 食品科学

背景情况:

  • 蛋过敏是儿童普遍存在的IgE介导的食物过敏.
  • 口服免疫疗法 (OIT) 涉及逐渐暴露于过敏原以减少过敏反应.
  • 高剂量OIT带来风险;低剂量蛋OIT (E-OIT) 的证据有限.

研究的目的:

  • 评估低剂量 (300毫克) E-OIT 诱导卵子过敏儿童脱敏的安全性和有效性.

主要方法:

  • 20名儿童被随机分配到即时治疗或观察组.
  • 评估累积耐受剂量 (CTD),特定IgE (sIgE),特定IgG4 (sIgG4) 和皮肤刺伤测试的反应.
  • 在整个研究期间监测不良事件.

主要成果:

  • E-OIT显著增加了CTD,从中位数14.1毫克增加到6000毫克.
  • 副作用不常见 (15.6%的剂量) 并且大多是轻微的.
  • 皮肤刺刺试验中,小腿直径下降,而sIgG4水平增加,sIgE水平下降.

结论:

  • 低维护剂量300毫克E-OIT是安全有效的治疗蛋过敏.
  • 这种方法引发了显著的临床和免疫学变化.
  • 低剂量E-OIT为儿科卵子过敏管理提供了有利的风险效益概况.