在患有eosinophilic慢性鼻炎的患者中,肺功能障碍和eosinophilia
Yuki Sonoda1, Yoshimasa Imoto1, Ayako Maegawa1
1Department of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
The journal of allergy and clinical immunology. Global
|September 22, 2025
概括
乙酸性慢性鼻炎 (ECRS) 与肺功能减弱和乙酸细胞升高有关,这表明有统一的气道状况. 一些ECRS患者在没有被诊断为喘的情况下表现出呼吸障碍和炎症,这表明了潜在的未被诊断的病例.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 埃索诺菲尔性慢性鼻炎 (ECRS) 是通过鼻多片 (NP) 中显著的埃索诺菲尔存在来定义的.
- 在NP患者中,全身性乙素,喘并发症和2型炎症之间的关系尚不清楚.
- 了解这些联系对于管理ECRS及其相关条件至关重要.
研究的目的:
- 为了研究慢性鼻炎患者肺功能和eosinophilia之间的相关性.
- 为了确定ECRS是否与下呼吸道卷入和全身氨酸性炎症有关.
- 探索ECRS,肺功能和未诊断的喘之间的联系.
主要方法:
- 198名慢性鼻炎患者接受了手术前的螺旋测量和部分呼出的氧化 () 测试.
- 患者被分为ECRS和非ECRS组,根据日本耐性异性慢性鼻炎流行病学调查得分进行分类.
- 鼻息肉 (NP) 炎症性细胞因子mRNA表达量化使用实时PCR;口腔致大鼻炎 (OMS) 作为对照组.
主要成果:
- 与非ECRS和OMS组相比,ECRS患者的FEV1/FVC比率和预测的空气流速明显较低.
- 在ECRS组中观察到更高的水平,与ECRS得分和肺功能受损相关.
- 在ECRS患者和患有>5%的外围好色素患者中,在NP中发现了2型细胞因子表达的升高.
结论:
- ECRS与呼吸功能显著受损有关,即使在没有被诊断为喘病史的患者中也是如此.
- 这些发现表明,NP中的氨酸性炎症可能会影响下呼吸道,支持一种氨酸性联合呼吸道疾病的概念.
- 建议在ECRS患者中早期识别和管理下呼吸道卷入.
相关概念视频
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.5K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.5K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
3.6K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.6K
01:22Chronic Obstructive Pulmonary Disease
2.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.3K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.1K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.1K
01:30Chronic Obstructive Pulmonary Disease-V: Nursing Management
5.1K
Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment
Assessment
5.1K