骨髓干细胞治疗心力衰竭患者的低射出分数:一个系统性审查
Azin Alizadehasl1, Seyedeh Fatemeh Hosseini Jebelli1, Yasamin Afsari Zonooz1
1Cardio-Oncology Research Center, Rajaie Cardiovascular Institute Tehran, Iran.
American journal of stem cells
|September 22, 2025
概括
骨髓干细胞 (BMSC) 疗法对心力衰竭 (HF) 患者具有低射出分数 (EF) 的患者显示出希望. BMSCs改善了心脏功能和运动能力,但没有显著影响重大心血管不良事件.
科学领域:
- 心脏病学 心脏病学
- 再生医学是一种再生医学.
- 干细胞疗法是一种干细胞疗法.
背景情况:
- 低射出分数 (EF) 的心力衰竭 (HF) 仍然是一个重大的临床挑战.
- 之前对骨髓干细胞 (BMSCs) 的研究已经产生了异质的结果.
- 需要进行系统审查,以巩固关于BMSC在低EF HF中的有效性的证据.
研究的目的:
- 在低EF (<45%) 的HF患者中系统地审查BMSCs对功能,临床,生活质量和主要不良心血管事件 (MACE) 的影响.
- 分析心声回声学参数的改善,运动能力和BMSC移植后的NYHA类.
主要方法:
- 在PubMed,Scopus,ClinicalTrials.gov,Cochrane图书馆,谷歌学者和参考数据库 (2000-2024) 的系统文献搜索.
- 包括14项随机对照试验 (RCT),涉及710名低EF的高压患者.
- 评估的结果包括LVEF,MACE,心声学指数 (LVEDV,LVESV),6-MWT,NYHA类和免疫反应.
主要成果:
- 在大多数 (9/14) 研究中,BMSCs移植改善了心声学参数,EF率和NYHA类.
- 在6分钟步行测试 (6-MWT) 中观察到显著改善.
- 在BMSCs移植和MACE或免疫反应之间没有发现显著的关联.
结论:
- 在低EF的HF患者中,BMSCs移植对心声学参数,EF率,NYHA类和运动能力产生积极影响.
- 在这种患者群体中,BMSCs治疗似乎对MACE和免疫反应安全.
- 进一步的研究可能会阐明BMSC治疗心力衰竭管理的最佳方案.
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