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脊柱操纵疗法治疗腰部疼痛与或没有坐骨神经炎和阿片类药物使用障碍之间的关联:一个回顾性队列研究

Robert J Trager^1,2,3, Zachary A Cupler⁴, Jordan A Gliedt⁵

¹Connor Whole Health University Hospitals Cleveland Medical Center Cleveland Ohio USA.

Health science reports

|September 22, 2025

概括

接受脊柱操纵疗法 (SMT) 治疗腰部疼痛 (LBP) 的患者患上阿片类药物使用障碍 (OUD) 的风险明显低于服用布洛芬的患者. 这项研究强调SMT作为LBP管理的潜在更安全的替代方案.

科学领域:

疼痛管理疼痛管理
综合医学是一个整体的医学.
公共卫生公共卫生

背景情况:

以前的研究表明,用于腰部疼痛 (LBP) 的脊椎操纵疗法 (SMT) 可能会降低阿片类药物处方率.
这种有关阿片类药物使用障碍 (OUD) 发展的临床意义尚不清楚.

研究的目的:

测试假设,先前未服用阿片类药物的成年人接受LBP的SMT,与匹配的对照人群相比,他们不太可能患上OUD.
调查SMT与布洛芬对LBP管理与阿片类药物使用有关的长期影响.

主要方法:

一个回顾性队列研究,使用TrinetX美国数据资源.
倾向性得分匹配被用来比较接受SMT治疗新LBP发作的患者与服用布洛芬的患者,控制OUD风险因素.
主要结局是OUD的风险比率 (RR),次要结局包括长期使用阿片类药物和阿片类药物处方率在2年的随访期间.

主要成果:

这项研究包括在匹配后,每个队列中的24,993名患者.
与ibuprofen队列相比,SMT接受者表现出OUD (RR=0.20),长期使用阿片类药物 (RR=0.23) 和任何阿片类药物处方 (RR=0.69) 的风险明显较低.
平均而言,SMT患者接受的阿片类药物处方数量较少 (1.0与2.1相比).

结论:

与接受ibuprofen治疗的成年人相比,接受SMT治疗新的LBP的成年人表现出患OUD的风险较低.
这些发现支持目前的指导方针,建议SMT作为LBP的第一线治疗.
需要进一步的研究来探索SMT在减轻阿片类药物相关危害中的作用.

关键词:

药物不良事件是药物不良事件.止痛药是一种止痛药.整形手术的治疗方法在阿片类药物阿片类药物.与阿片类药物相关的疾病.脊柱操纵是一种脊柱操纵.

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