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头发皮质醇,脱水氨和慢性压力相关疾病中的感知压力之间的关联:系统性审查和元分析
Ravish Huchegowda1, Ranganath R Kulkarni2, Somashekhar Bijjal3
1Dept. of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.
Indian journal of psychological medicine
|September 22, 2025
概括
头发皮质醇与脱水氨 (DHEA) 的比率显示出作为慢性压力生物标志物的潜力. 然而,目前的研究不足以证实其在评估感知压力的临床实用性.
科学领域:
- 内分泌学 在内分泌学.
- 心理神经内分泌学心理学
- 生物标志物研究 生物标志物研究
背景情况:
- 头发皮质醇和脱水氨 (DHEA) 度作为非侵入性生物标志物,用于下丘脑-垂体-上腺轴的功能.
- 头发皮质醇:DHEA比率理论上反映了催化和合成活性之间的平衡,可能表明慢性压力.
- 对于评估慢性压力的头发皮质醇:DHEA比率的临床实用性仍然不清楚.
研究的目的:
- 系统地审查和评估皮质醇:DHEA比率与慢性压力暴露的成年人的感知压力之间的关联.
- 综合现有研究的证据,以确定该比率作为压力生物标志物的可靠性.
主要方法:
- 按照PRISMA指南进行了系统审查,搜索了5个电子数据库和灰色文献,截至2025年3月5日.
- 包括的研究涉及有记录的慢性压力暴露的成年人,报告了头发皮质醇和DHEA水平以及经过验证的感知压力指标.
- 进行了对相关系数和组比较的元分析,并使用修改后的唐斯和黑名单评估偏差风险.
主要成果:
- 八项研究符合纳入标准. 两项研究的元分析发现,皮质醇:DHEA比率和感知压力 (ρ = 0.09) 之间没有显著的关联.
- 然而,对比高压力与低压力组的三项研究的分析显示,中度,统计学上显著的聚合效应 (Hedges' g = 0.69) 与实质性的异质性 (I2 = 77.17%).
- 证据的整体确定性被评为非常低,原因是样本规模小,发现不一致,尽管偏差风险中等至低.
结论:
- 头发皮质醇:DHEA比率作为慢性压力的标志物具有生物学可信性.
- 目前的证据不足以支持其用于评估感知压力的临床应用.
- 需要进一步标准化,纵向研究来确定头发皮质醇:DHEA比率的诊断和预后价值.
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