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酸增强了等离子体激活水的抗菌活性

Laura A McClenaghan¹, Thomas P Thompson¹, Akash Shambharkar¹

¹Biofilm Research Group, School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK.

|September 22, 2025

概括

将酸添加到血激活水 (PAW) 中,通过产生反应性物种 (RIS) 来显著提高其消毒能力. 这种用酸 (KI) 增强的PAW迅速使细菌和生物膜失活,提供可持续的消毒解决方案.

科学领域:

反应性物种的化学成分
抗微生物技术抗微生物技术
处理水处理水处理水处理

背景情况:

血激活水 (PAW) 使用活性氧和物种 (ROS/RNS) 进行消毒.
在酸性环境中,PAW产生过氧化 (H2O2) 和酸盐 (NO3-).
现有的PAW消毒显示出对某些微生物的速度和有效性的局限性.

研究的目的:

通过添加低度的化 (KI) 来研究增强PAW的杀菌特性.
阐明KI增强PAW消毒背后的机制,重点关注反应性物种 (RIS) 生产.
评估随着时间的推移,PAW与KI的稳定性和抗菌能力.

主要方法:

由火花生成的PAW是用不同度的KI (10-100μM) 制备的.
化学分析量化了H2O2,NO3和RIS的度.
对Escherichia coli,Listeria monocytogenes和Salmonella enterica的浮游生物细胞和生物膜进行了抗菌疗效测试.
使用Scavenger测试来确定参与增强杀死机制的关键反应物种.

主要成果:

KI的添加剂量取决于PAW中的H2O2和NO3水平.
使用KI的PAW实现了大肠杆菌和L. monocytogenes浮游生物细胞的快速无活化 (<3分钟),明显快于单独使用PAW.
使用PAW+KI.KI,在10分钟内完全消除了L. monocytogenes和E. coli生物膜.
沙门氏菌表现为部分无活化和减少生物膜根除,表明物种特异性耐受性.
清洁剂试验表明H2O2和单片氧的重要作用,而臭氧和超氧化物是不可用的.

结论:

PAW和KI的组合产生了一个强大的in situRIS生成系统,显著增强了抗菌活性.
该机制涉及血产生的H2O2和NO3-,KI氧化到RIS (HIO),PAW氧化剂的强化,以及HIO造成的膜损伤.
PAW-KI在至少14天内表现出极好的稳定性,保持了抗菌能力.
该系统提供了一个减少残留物,环境可持续的消毒平台,对食品安全,临床环境和卫生设施具有吸引力.

关键词:

生物膜是一种生物膜.冰冷的等离子体是什么?食品病原体的食物病原体这种酸是酸的.用等离子体激活的水.化 (酸) 是一种酸盐.沙门氏菌是一种沙门氏菌.

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