二碳酸盐林格溶液对进行皮肤穿透冠状动脉干预的患者对对比后急性损伤的预防作用
Jialin Liu1, Wen Zhao1, Baobao Feng1,2
1Department of Emergency, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Frontiers in pharmacology
|September 22, 2025
概括
二碳酸灵格溶液 (BRS) 在冠状动脉血管学 (CAG) 和皮肤冠状动脉干预 (PCI) 后,有望预防对比后急性损伤 (PC-AKI). 这项研究发现,与正常盐水相比,在接受BSR的患者中,PC-AKI的发病率明显较低.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 对比后急性损伤 (PC-AKI) 是冠状动脉血管造影 (CAG) 和皮肤冠状动脉干预 (PCI) 后的常见并发症.
- 二碳酸盐灵格溶液 (BRS) 已在减少手术后急性损伤 (AKI) 和手术和重症患者群体中的酸疾病方面表现出有效性.
- 关于BRS用于预防PC-AKI的应用存在有限的研究.
研究的目的:
- 研究BRS在接受CAG或PCI的患者中预防PC-AKI的有效性和安全性.
- 为了比较用BRS治疗的患者和用正常盐水 (NS) 治疗的患者之间的PC-AKI发病率.
主要方法:
- 一项前性随机研究,涉及冠状动脉样性心脏病和2-3b期慢性病 (CKD) 的患者.
- 参与者接受了BRS或NS以1mL/kg/h的速度从手术前3小时到手术后4小时的水分.
- 血清肌素,囊素C和NGAL水平被监测,PC-AKI作为主要终点. 二级终点包括替代疗法 (RRT) 和主要不良心血管事件 (MACE).
主要成果:
- 在BRS和NS组之间没有观察到基线特征或Cys-C,NGAL和电解质变化的显著差异.
- 与NS组 (9.3%) 相比,BRS组的PC-AKI发生率显著较低 (1.3%). (P = 0.029).与NS组相比,BRS组的PC-AKI发生率显著较低 (9.3%).
- 多变量逻辑回归表明BRS减少PC-AKI发病率的趋势 (P = 0.054).
结论:
- 在接受CAG/PCI的轻度至中度功能障碍患者中,BRS可能比NS更适合预防PC-AKI.
- 需要进一步的研究来证实这些发现,并建立最佳的BRS使用在这个患者群体的协议.
关键词:
对比对比对比的对比对比对比的对比对比对比的对比对比对比对比的对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比对比冠状动脉动脉图 (Coronary Angiography) 是一种冠状动脉动脉图.补充水分 补充水分 补充水分通过皮肤进行冠状动脉干预.在对比后的急性损伤.二碳酸是林格尔溶液中的一种.
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