G蛋白结合受体介导纤维化:对脏疾病药物开发的重点关注
Hui Wang1,2, Mengfan Yang2, Xiongfeng Liu1
1Institute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in pharmacology
|September 22, 2025
概括
G蛋白结合受体 (GPCRs) 是纤维化 (RF) 的关键调节者. 向GPCRs为治疗慢性病 (CKD) 提供了希望,但临床翻译面临挑战.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 纤维化 (RF) 是渐进性病的常见终点,其特征是细胞外基质 (ECM) 沉积过多.
- G蛋白结合受体 (GPCRs) 在调节功能和对损伤的纤维性反应方面至关重要.
- 目前慢性病 (CKD) 的治疗方法缺乏针对RF的主要驱动因素的药物.
研究的目的:
- 系统地审查GPCRs,这些GPCR是射频病理生物学中的核心,以及它们的治疗潜力.
- 检查RF中的特定GPCRs,包括内末素,血管素,化学激素和腺素受体.
- 探索GPCRs在纤维化期间代谢和机械传导信号中的新兴作用.
主要方法:
- 系统的文献审查.
- 对涉及纤维化GPCRs的分析.
- 对GPCR向疗法的转化挑战的评估.
主要成果:
- 在纤维生成中,GPCRs调节炎症,亲纤维细胞转换,代谢和机械传导.
- 特定的GPCRs,如内甲蛋白,血管素,化学因子和腺素受体,因其作用而被突出.
- 在RF中对GPCRs的显著机制理解已经取得了进展.
结论:
- GPCRs是中断纤维化进展的高价值标.
- 以GPCR为导向的抗纤维菌疗法的临床转化受到目标类型,生物分布和物种差异的阻碍.
- 需要进一步的研究来克服有效的射频治疗的转化障碍.
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