维生素D不足和心血管参与全身性硬化症:与心声学参数和风险因素的关联
Gianluca Pagnoni1, Dilia Giuggioli2,3, Marco de Pinto2
1Cardiology Unit of Emergency Department, Guglielmo da Saliceto Hospital, 29121, Piacenza, Italy.
International journal of cardiology. Cardiovascular risk and prevention
|September 22, 2025
概括
维生素D不足在全身性硬化症 (SSc) 患者中很常见,并且与心脏功能障碍有关. 监测维生素D可能有助于管理SSc.中的心血管风险.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
背景情况:
- 系统性硬化症 (SSc) 是一种自身免疫性疾病,由于纤维化和血管功能障碍,心血管风险很高.
- 维生素D在SSc心血管并发症中的作用尚不清楚.
- 这项研究调查了SSc患者的维生素D水平和心脏功能之间的关联.
研究的目的:
- 评估低维生素D水平与SSc患者心室功能障碍的心声学指标之间的关系.
- 评估SSc.中维生素D不足与心血管风险因素之间的关联.
- 探索维生素D对系统性硬化症中心血管健康的潜在影响.
主要方法:
- 一项回顾性观察性研究包括160名SSc患者.
- 根据血清25-基维生素D水平分组患者:不足 (<30 ng/mL) 与正常 (≥30 ng/mL).
- 进行了心声学和对心血管风险因素的评估.
主要成果:
- 维生素D不足很普遍 (68.9%),并与肺动脉压升高,TAPSE/PAPs比率降低,腹腔间隔膜厚度增加和左心室末腹径更大有关.
- 在SSc患者中,低维生素D水平与高血压,脂质失调以及超重/肥胖有显著的相关性.
- 在维生素D不足和糖尿病或吸烟之间没有发现显著的关联.
结论:
- 维生素D不足可能导致系统性硬化症中心血管功能障碍.
- 监测维生素D水平可以提高SSc患者的心血管风险评估.
- 需要进一步的研究来确定是否补充维生素D可以改善心脏病的结果.
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