全球和中国急性髓性白血病负担的趋势 (1990-2021):基于GBD研究的综合分析
Xiaojing Lu1, Xin Peng1, Yunxiang Zhang1
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in medicine
|September 22, 2025
概括
全球急性髓性白血病 (AML) 死亡人数增加,但中国的年龄调整率下降. 有针对性的预防和老年治疗策略对于管理这种不断增长的癌症负担至关重要.
科学领域:
- 流行病学 流行病学
- 血液学 血液学 血液学
- 公共卫生 公共卫生
背景情况:
- 急性髓性白血病 (AML) 是一个重大的全球健康挑战.
- 本研究研究了从1990年到2021年的AML负担的长期趋势,重点关注全球和中国的流行病学模式.
研究的目的:
- 分析AML死亡率,发病率,流行率和DALYs的全球和中国趋势.
- 评估吸烟和高BMI等风险因素对AML负担的影响.
- 为了确定AML负担的人口差异,特别是在年龄和性别方面.
主要方法:
- 使用的全球疾病负担 (GBD) 1990-2021年数据用于AML指标.
- 使用Joinpoint回归分析年龄标准化利率 (ASR) 并计算年度百分比变化 (APC/AAPC).
- 评估了吸烟,高BMI和职业暴露对AML负担的贡献.
主要成果:
- 全球AML死亡人数增加了73.8%,年龄标准化死亡率 (ASMR) 增加了17.45%.
- 中国的ASMR下降了14.76%,与全球趋势 (-0.83%AAPC) 相比,DALY下降幅度更大 (-2.40%AAPC).
- 65岁以上的男性和个人经历了不成比例的负担;吸烟仍然是主要的危险因素,而高BMI显示了归因负担的最快增长.
结论:
- 尽管全球AML负担的绝对增加,但中国的年龄调整指标正在改善,这可能是由于医疗保健的改善.
- 迫切需要有针对性的预防策略,风险因素控制和以老年为中心的AML管理方法.
相关概念视频
01:27Disorders of Leukocytes
1.8K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.8K
02:07Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
01:15Differentiation of Common Myeloid Progenitor Cells
3.9K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.9K