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罗皮瓦卡因对比布皮瓦卡因在儿科桃体切除术:一个系统性审查和元分析
Ebraheem Albazee1,2, Khaled Alenezi3, Abdulwahab Alkandari3
1Otorhinolaryngology-Head and Neck Surgery Kuwait Institute for Medical Specializations (KIMS) Kuwait City Kuwait.
罗皮瓦卡因和布皮瓦卡因在儿童的桃体切除术后提供类似的疼痛缓解. 罗皮瓦卡因在手术后24小时减轻疼痛方面表现出轻微的优势,安全性概况相似.
科学领域:
- 麻醉学 麻醉学
- 儿科手术 儿科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 桃体切除术是一种常见的儿科手术手术.
- 术后疼痛管理对于康复至关重要.
- 局部麻醉剂透到桃体里是控制疼痛的潜在策略.
研究的目的:
- 为了比较罗皮瓦卡因与布皮瓦卡因在儿科桃体切除术期间在桃体洞中局部麻醉透的止痛效果和安全性.
- 评估术后疼痛得分,第一次止痛需要的时间和并发症率.
主要方法:
- 对符合条件的随机对照试验 (RCT) 进行了系统审查和元分析.
- 数据来源包括CENTRAL,PubMed,科学网,Scopus和谷歌学者.
- 使用Cochrane的偏差风险工具 (RoB-2) 评估了偏差风险.
- 标准化平均差异 (SMD) 和风险比率 (RR) 与95%的置信区间 (CI) 用于数据合成.
主要成果:
- 分析了7项涉及375名儿科患者的RCT.
- 在桃体切除术后1,2,4,6-8小时和12小时,在罗皮瓦卡因和布皮瓦卡因之间没有观察到疼痛评分的显著差异.
- 罗皮瓦卡因在手术后24小时表现出具有统计学意义的优异止痛作用 (SMD = -0.23,95% CI [-0.43,-0.03]).
- 在这两种药物之间,第一次止痛需要的时间和并发症率是可比的.
结论:
- 罗皮瓦卡因和布皮瓦卡因在儿科桃体切除术中对局部麻醉透的临床 analgesic 疗效和安全性表现相似.
- 罗皮瓦卡因可能在术后24小时减轻疼痛方面提供轻微的优势.
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