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探索FAPI PET在软组织肉瘤中的诊断和治疗作用:系统性审查
Marwah Abdulrahman1, Frederik Giesel2, Andrew M Scott3,4,5
1Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan.
Nuclear medicine and molecular imaging
|September 22, 2025
概括
与FDG PET/CT相比,纤维细胞激活蛋白抑制剂 (FAPI) PET/CT对软组织肉瘤 (STS) 的诊断准确度更高. 基于FAPI的放射性连接体疗法为先进的STS提供了安全有效的治疗选择.
科学领域:
- 在瘤学瘤学.
- 核医学是一种核医学.
- 放射化学 放射化学是指辐射化学.
背景情况:
- 软组织瘤 (STS) 是一组异质的恶性瘤.
- 准确的诊断,分期和治疗监测对于STS管理至关重要.
- 纤维细胞激活蛋白 (FAP) 在许多STS中过度表达,使其成为潜在的治疗点.
研究的目的:
- 系统地审查FAPI PET在STS中的诊断和治疗应用.
- 为了比较FAPI PET/CT与FDG PET/CT在STS中的性能.
- 评估基于FAPI的放射性联体疗法 (RLT) 在STS中的疗效和安全性.
主要方法:
- 在PubMed,Scopus和Web of Science的系统文献搜索,截至2024年10月15日.
- 包括36项研究,涉及大约30个STS亚型的316名患者.
- 综合有关诊断准确度,病变检测和治疗结果的数据.
主要成果:
- 与FDG PET/CT相比,FAPI PET/CT显示出优越的瘤划界和更高的SUVmax/瘤与背景比率,特别是在血管瘤中.
- 在各种STS亚型中,FAPI吸收指标可靠地与FAP免疫组织化学相关.
- 对于复发性/转移性STS的分期和重新分期,FAPI PET/CT显示出更高的准确性和更好的病变检测.
- 基于FAPI的RLT在36名患者中16名患者中稳定了疾病,具有良好的安全性.
结论:
- FAPI PET/CT是一种高精度的成像方式,用于诊断和监测软组织肉瘤,性能优于FDG PET/CT.
- 基于FAPI的放射性连接体疗法代表了对具有挑战性的STS病例的有希望和安全的治疗策略.
- 进一步的研究是有必要的,以优化基于FAPI的STS管理中的theranostics.
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