抑郁症对老年人身体活动和认知功能之间的关联的调解作用
HuanRui Zhang1, Wen Tian1, GuoXian Qi1
1Department of Geriatric, The First Hospital of China Medical University, Shenyang, China.
Frontiers in aging neuroscience
|September 22, 2025
概括
中度至高强度的娱乐活动可能会减少老年人的认知衰退. 抑郁症在这种关系中发挥着关键作用,它调解了娱乐活动对认知功能的影响.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 身体活动 (PA) 与减少认知能力下降有关.
- 抑郁症在PA与认知衰退关系中的调解作用仍然不清楚.
研究的目的:
- 调查不同类型的PA与老年人认知功能之间的关联.
- 检查抑郁症对PA和认知衰退之间的关系的调解效应.
主要方法:
- 来自NHANES (2011-2014) 的2681名老年人 (≥60岁) 的分析.
- 评估PA (娱乐,工作,步行/骑自行车),抑郁症 (PHQ-9) 和认知功能 (AFT,DSST,复合z-score).
- 使用了权重多变量线性回归和调度建模.
主要成果:
- 中度至高强度的娱乐活动和较低的抑郁症得分与更好的认知功能有关.
- 抑郁症调解了娱乐活动和认知功能之间的关系 (AFT:6.5%,DSST:12.3%,复合z-score:10.5%).
- 结果与敏感性分析一致,不包括有中风病史的参与者.
结论:
- 适度到高强度的娱乐活动,而不是其他PA类型,与老年人认知能力下降的减少有关.
- 抑郁症是娱乐活动与认知功能之间的关系的重要调解者.
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