基于叙事的精神教育干预对精神分裂症患者药物坚持的影响:一个多中心,并行组随机对照试验
Zhao Liu1, Dian Zhu1, Zhiwen Zhang2
1School of Design, Shanghai Jiao Tong University, Shanghai, 200240, PR China.
EClinicalMedicine
|September 22, 2025
概括
基于叙述的精神教育干预措施显著改善了精神分裂症患者的药物坚持和态度. 这些对药物坚持和态度的积极影响在3个月的随访中持续存在.
科学领域:
- 精神病学是一个精神病学.
- 数字健康数字健康
- 临床心理学 临床心理学
背景情况:
- 药物不服药是精神分裂症管理的一个主要问题,影响患者的30-70%.
- 数字干预提供了一种潜在的解决方案,以改善坚持和结果.
- 这项研究评估了对稳定的精神分裂症患者进行基于叙事的精神教育干预.
研究的目的:
- 评估基于叙事的精神教育干预措施的有效性.
- 改善稳定精神分裂症患者的药物坚持,态度,心理状态和生活质量.
主要方法:
- 进行了一项多中心,并行组随机对照试验,对结果进行了盲目评估.
- 参与者接受了标准护理或标准护理以及为期3个月的基于叙事的精神教育干预.
- 药物坚持 (MMAS-8) 和态度 (DAI-10) 是共同主要的结局,在基线,干预后和1个月和3个月的随访评估.
主要成果:
- 干预组在干预后的药物坚持 (P=0.02) 和态度 (P=0.02) 显著改善,在3个月的随访中持续 (P<0.001).
- 老年患者报告说,他们的态度更好,临床症状更少.
- 较低的教育水平与更好的药物坚持和社会关系相关.
结论:
- 基于叙述的精神教育干预措施有效地提高了精神分裂症患者的药物坚持.
- 观察到的坚持和态度的改善表明了持续的影响.
- 进一步的研究应探讨在不同人群中长期的有效性和实施.
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