前列腺癌查试验的绩效指标概述
Meike J van Harten1, P M Willemse2, R C N van den Bergh1
1Erasmus University Medical Centre, Cancer Institute, Rotterdam, The Netherlands.
European urology open science
|September 22, 2025
概括
这项研究审查了前列腺癌 (PCa) 查试验,为未来的举措,如PRAISE-U.建立绩效指标 (PI). 在PI中存在很大的差异,强调在比较查有效性时需要考虑研究差异.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 前列腺癌 (PCa) 查是一个有争议的话题.
- 欧盟委员会建议在2021年进行基于风险的,基于人口的PCa查的试点研究.
- PRAISE-U项目旨在使用绩效指标 (PI) 评估选试点的可行性和有效性.
研究的目的:
- 提供从主要PCa选试验中获得的PI的全面概述.
- 在新的选举措中,如PRAISE-U.中,为计算PI建立一个参考值.
- 将不同查试验中的PI进行比较,并确定影响结果的因素.
主要方法:
- 一个基于人口的PCa查试验的叙述性综述,至少有1000名参与者.
- 提取和统一计算关键绩效指标:参与率,查阳性,风险分层使用,MRI和活检率,癌症检测率.
- 对十项主要PCa选试验的分析.
主要成果:
- 参与率差异很大 (12%-89%),受研究年,设计和参与者的年龄的影响.
- PSA阳性率在0.8%至29%之间,与年龄,重复PSA测试和社会经济因素有关.
- 临床显著的PCa检测率从41%到82%不等.
结论:
- 提出的PI可以作为正在进行和未来的PCa选研究的基准.
- 由于时间段,人口,同意策略和诊断算法之间的差异,PI存在显著差异.
- 仔细考虑这些因素对于准确比较国家查试点至关重要.
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