低收入和中等收入国家的高血压和痴呆风险之间的关联:系统审查
Josephine E Lindhout1,2, Marieke P Hoevenaar-Blom1,2, Jan Willem van Dalen3
1Department of Public and Occupational health, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
JAR life
|September 22, 2025
概括
高血压 (高血压) 在低收入和中等收入国家 (LMICs) 增加了痴呆和轻度认知障碍的风险. 需要更多的研究,特别是来自非洲和拉丁美洲,进行区域比较.
科学领域:
- 全球健康 全球健康
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 痴呆症的患病率在低收入和中等收入国家 (LMICs) 迅速增加.
- 高血压是痴呆症的一个关键风险因素,在LMIC中患病率很高,控制能力很差.
- 关于高血压和痴呆症的现有证据主要来自高收入国家.
研究的目的:
- 系统地审查LMIC中血压与痴呆/认知之间的关联的证据.
- 为了比较LMICs内的不同地理区域的发现.
主要方法:
- 在PubMed,Embase,PsycINFO和全球指数Medicus的系统文献搜索.
- 包括从LMIC中对高血压/静脉压和痴呆症,轻度认知障碍 (MCI) 或认知进行的纵向研究 (≥6个月的随访,≥500名参与者).
- 偏差风险评估使用修改后的纽卡斯尔-太华尺度.
主要成果:
- 包括26项研究:19项来自亚洲,6项来自拉丁美洲,1项来自非洲.
- 高血压与发生痴呆症 (RR 1.26) 和MCI (RR 1.19) 的风险增加有关.
- 跨研究的高血压和认知结果的异质运行.
- 拉丁美洲和非洲的有限研究阻止了可靠的区域比较.
结论:
- 高血压是LMIC中痴呆症和认知障碍的重要危险因素.
- 需要进一步的研究,特别是来自非洲和拉丁美洲等代表性不足的地区.
- 评估高血压和认知结果的标准化方法对于未来的研究至关重要.
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