相关实验视频
Updated: Jan 17, 2026

08:41
Mouse Round Spermatid Injection
Published on: January 26, 2024
1.4K
WEE2基因多态与受精失败的关联在接受细胞内质精子注射的女性中
Zahraa Hamid Mohan Al-Gawwam1, Rasha Hamzah Abdulhussein2, Hala Saad Abed3
1Department of Anatomy, Hammurabi College of Medicine, University of Babylon, Hillah, Babylon, 51002, Iraq.
International journal of women's health
|September 22, 2025
概括
WEE2基因中的遗传变异与接受细胞内质精子注射 (ICSI) 的女性受精失败有关. WEE2 rs1476640多态,特别是C等位基因,增加了受精失败的风险,突出了其在生殖医学中的重要性.
科学领域:
- 生殖医学 生殖医学
- 人类遗传学 人类遗传学
- 分子生物学分子生物学
背景情况:
- 不孕不育和怀孕流产是生殖医学中的重大问题,通常源于影响卵细胞成熟的遗传因素.
- WEE2基因编码了一个关键的卵细胞特异性激酶,它参与了半分裂和受精.
- WEE2基因变异与卵细胞成熟停止和完全受精失败 (TFF) 有关,特别是在接受辅助生殖技术的妇女中.
研究的目的:
- 调查WEE2基因多态和受精失败在接受细胞内精子注射 (ICSI) 的女性之间的关联.
主要方法:
- 一项前性比较研究,涉及137名接受ICSI的不孕妇女.
- 收集了外周血液样本进行遗传分析.
- 对WEE2基因变体rs1476640的基因定型使用定制的聚合酶连锁反应-限制片段长度多态化 (PCR-RFLP) 试验进行.
主要成果:
- WEE2基因多态 rs1476640与受精结果显著相关 (p < 0.0001).
- 发现WEE2 rs1476640的T基因对受精失败有保护作用.
- WEE2 rs1476640的C等位基因显著增加了受精失败的风险 (OR = 9.06;95% CI: 3.27-25.14).
- 在孕妇和非孕妇之间观察到不孕持续时间,卵细胞数和子宫内膜厚度的显著差异 (p < 0.05).
结论:
- 在接受ICSI的妇女中,WEE2 rs1476640多态性与受精失败有显著的关联.
- 识别患有这种WEE2变异的患者可能有助于对不孕不育的风险分层.
- 查WEE2rs1476640可能有助于个性化的不孕症治疗策略.
相关概念视频
Meiosis II
207.1K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
207.1K
In Vitro Fertilization
894
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
894
Infertility in Males
528
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
528
Fertilization
89.9K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
89.9K
Infertility in Females
3.7K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
3.7K
Nondisjunction
4.8K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
4.8K

