机器学习分析希腊患者对仿制药的看法:一项基于调查的研究
Konstantinos Kassandros1, Evridiki Saranti1, Evropi Misailidou1
1Laboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Frontiers in drug safety and regulation
|September 22, 2025
概括
希腊患者是希腊患者.
科学领域:
- 药物经济学和医疗服务研究研究 药物经济学和医疗服务研究
- 患者的行为和态度
- 医疗信息学和机器学习
背景情况:
- 对仿制药的患者怀疑,阻碍了它们在希腊的市场透.
- 了解患者的看法对于促进通用药物的接受至关重要.
- 通用药的节省成本潜力是公认的,但由于患者的态度,尚未完全实现.
研究的目的:
- 调查希腊患者对仿制药的看法和态度.
- 确定影响仿制药的接受和市场透的因素.
- 使用机器学习预测患者愿意转向通用替代品的意愿.
主要方法:
- 一种混合方法的方法,结合了描述性统计和机器学习模型.
- 分析了2,617名成年参与者的调查答案 (2017年2月 - 2021年6月).
- 优化和比较了后勤回归,支持向量机,随机森林,梯度提升和XGBoost模型.
主要成果:
- 医疗保健提供者是患者关于仿制药的信息的主要来源.
- 机器学习模型确定了患者的知识和医疗保健专业人士的影响力是通用药物接受的关键预测因素.
- 随机森林模型在预测患者转换意愿方面取得了最高的准确性.
结论:
- 有信息的医疗保健提供者在塑造患者对仿制药的态度方面发挥着至关重要的作用.
- 这项希腊研究的见解对改善仿制药的接受性具有全球影响.
- 限制包括方便采样和自我报告的数据,需要谨慎的概括.
相关概念视频
Assessment of the Gastrointestinal System II: Health Perception Pattern
456
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
456
The Placebo Effect
6.8K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.8K
Drug Dosing: Geriatric Patients
228
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
228
Analysis of Population Pharmacokinetic Data
682
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
682
Pharmacodynamics in Geriatric Patients: Effects of Age
188
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
188
Assessment of the Gastrointestinal System I: Subjective Data
627
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
627


