人工智能用于优化药理疗法的益处并最大限度地降低药理疗法的风险:挑战和机遇
Salvatore Crisafulli1, Francesco Ciccimarra2, Chiara Bellitto2
1Department of Medicine, University of Verona, Verona, Italy.
Frontiers in drug safety and regulation
|September 22, 2025
概括
药理学中的人工智能 (AI) 利用现实世界的数据来评估药物安全性. 人工智能为营销后监测和改善临床实践提供了机会和挑战.
科学领域:
- 药理学 药理学是指药理学的学科.
- 医疗信息学 医疗信息学
- 人工智能的人工智能
背景情况:
- 来自不同来源的电子医疗数据 (现实世界数据) 的指数增长.
- 信息技术,计算能力和分析方法 (生物信息学,人工智能) 的进步提高了数据的利用率.
- 现实世界的证据生成对于改善临床实践至关重要.
研究的目的:
- 提供AI在药理学中的机遇和挑战的概述.
- 专注于人工智能在药物营销后安全评估中的作用.
- 突出卫生专业人员对医学AI教育的需要.
主要方法:
- 对当前文学进行叙述性回顾.
- 对医疗保健数据中人工智能应用的分析.
- 在药物安全和营销后监督方面探索AI.
主要成果:
- 人工智能可以通过大规模数据分析快速生成证据.
- 成功的AI应用存在于医疗图像处理,诊断,预测和治疗管理领域.
- 人工智能为加强药物营销后安全评估提供了重大机会.
结论:
- 人工智能在药理学和药物安全方面具有变革性的潜力.
- 解决挑战和教育专业人士是实现人工智能的好处的关键.
- 整合人工智能对于推进基于证据的医学和患者护理至关重要.
相关概念视频
Structure-Activity Relationships and Drug Design
1.7K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.7K
Drug Discovery: Overview
11.1K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
11.1K
Drug Administration and Therapy Phases: Overview
1.3K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
1.3K
Issues And Trends In Healthcare Delivery System
6.1K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
6.1K
Drug Therapy
245
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
245
Dosage Regimen: Individualization
166
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
166

