接种COVID-19疫苗后的月经障碍:使用系统搜索的审查
Veerle R Smaardijk1, Rana Jajou1, Agnes Kant1,2
1Netherlands Pharmacovigilance Centre Lareb, Hertogenbosch, Netherlands.
Frontiers in drug safety and regulation
|September 22, 2025
概括
接种COVID-19疫苗可能会导致女性的暂时月经变化. 这项系统性审查发现了月经障碍的证据,如周期长度变化和接种疫苗后出血,尽管效应通常是轻微的和短暂的.
科学领域:
- 疫苗学 疫苗学 疫苗学
- 生殖健康 生殖健康
- 公共卫生 公共卫生
背景情况:
- 在COVID-19疫苗接种后经常报告月经障碍.
- 在Moderna和Pfizer的疫苗产品信息中指出了大量的月经出血.
研究的目的:
- 系统地审查和总结有关COVID-19疫苗接种后月经障碍风险的现有文献.
主要方法:
- 在PubMed上进行了系统的文献搜索,遵循PRISMA指南.
- 包括到2023年8月15日以英语和荷兰语出版的定量研究.
- 分析了61项研究 (40项横截面研究,18项队列研究,3项自我控制的病例系列).
主要成果:
- 所有包括的研究都报告了疫苗接种后至少一个月经障碍的发病率增加.
- 通常报告的疾病包括周期长度的变化,出血量,月经持续时间,疼痛和突破性出血.
- 在各种COVID-19疫苗类型和剂量后观察到影响.
结论:
- 目前的证据表明,COVID-19疫苗和生殖年龄妇女的月经变化之间存在潜在联系.
- 虽然变化似乎是暂时的和轻微的,但妇女和医疗保健提供者的意识至关重要.
- 需要进一步进行纵向研究,以解决当前研究设计的局限性.
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