(Rutaceae) 黄类药物通过调节结肠微生物群和miRNA/mRNA网络来改善便秘
Yong Wen1, Yu Zhan2,3, Li-Juan Du4,5
1Department of Traditional Chinese Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
青果实不成熟的黄 (AFIF) 通过改善肠道微生物群和调节miRNA-mRNA网络,有效治疗小鼠的抗生素诱导的便秘 (AC). 这种天然化合物增强了肠道的运动和功能,提供了一个有前途的治疗方法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 抗生素诱导的便秘 (AC) 是一个重大的临床挑战.
- 青果实不成熟的黄酸 (AFIF) 是青果实不成熟的关键化合物,已知有效治疗便秘.
研究的目的:
- 在已建立的AC小鼠模型中研究AFIF的治疗机制.
- 探索AFIF对结肠微生物群和基因表达特征的影响.
主要方法:
- 使用抗生素混合物的AC小鼠模型的建立.
- 每天给小鼠使用AFIF的食剂.
- 使用H&E和PAS染色的组织学分析.
- 用于结肠微生物群分析的16sRNA测序.
- 转录组测序用于miRNA和mRNA表达形状.
主要成果:
- 在AC小鼠中,AFIF治疗显著改善了便秘症状,包括增加便量和肠道过渡率.
- AFIF改善了结肠病理损伤和调节了关键神经递质水平,如乙胆 (ACH),胃素 (GAS),莫提林 (MTL),物质P (SP) 和血管活性肠 (VIP).
- AFIF调节了结肠微生物群的组成,并调节了参与细胞结合和神经活性功能的miRNA-mRNA网络,特别是将mmu-miR-5100和mmu-miR-18b-5p连接起来以向mRNA.
结论:
- 在抗生素引起的便秘中,AFIF显示出显著的治疗潜力.
- 该机制涉及结肠微生物群和特定miRNA-mRNA网络的调节.
- 这些发现为AFIF在治疗便秘的临床应用提供了理论基础.
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