在中期阶段 (BCLC B 阶段) 肝细胞癌的治疗中进行的辩论和进展
Jianan Jiang1, Yinbiao Cao2, Shang Gao2,3
1School of Medicine, Tsinghua University, Beijing 100084, China.
iLIVER
|September 22, 2025
概括
肝细胞癌 (HCC) 阶段需要改进,超出巴塞罗那诊所肝癌 (BCLC) 系统. 对于中期HCC的高级分层可能会个性化治疗以获得更好的结果.
科学领域:
- 肝病学和瘤学 肝病学和瘤学
- 临床试验的设计
- 翻译医学是一种翻译医学.
背景情况:
- 肝细胞癌 (HCC) 的全球发病率正在增加,需要精确的分期才能有效治疗.
- 巴塞罗那诊所肝癌 (BCLC) 阶段系统是HCC分类的标准,但患者异质性限制了跨动脉化学栓塞 (TACE) 疗效.
- 保持肝功能对于改善HCC患者的整体存活率至关重要.
研究的目的:
- 探索中期HCC (BCLC B阶段) 的高级分层方法.
- 评估目前和新兴的治疗策略超出TACE对特定的HCC亚群.
- 评估个性化疗法的潜力,以改变HCC管理.
主要方法:
- 关于HCC分期和治疗指南的当前文献的综述.
- 对中期HCC的高级分层标准的分析.
- 评估临床试验,调查向疗法和个性化方法.
- 评估在HCC管理中从TACE中心转向个性化医疗的转变.
主要成果:
- 像BCLC这样的现有分期系统在解决中期HCC的患者异质性方面存在局限性.
- 超动脉化学栓塞 (TACE) 是标准的,但由于瘤负担和肝功能的变化,它并不普遍有效.
- 先进的分层和个性化向疗法显示出在特定的HCC患者亚组中优化结果的希望.
结论:
- 对于中期HCC的统一治疗方法是不够的.
- 高级分层对于将治疗量身定制到个别患者的个人资料至关重要.
- 个性化向治疗是改善肝细胞癌管理的未来方向.
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