使用商业合成计算机断层扫描解决方案用于脑MRI-only放射治疗治疗计划的临床验证
Lamyaa Aljaafari1,2,3, Richard Speight2,4, David L Buckley1
1Leeds Institute of Cardiovascular & Metabolic Medicine (LICAMM), University of Leeds, Woodhouse, Leeds LS2 9JT, United Kingdom.
Technical innovations & patient support in radiation oncology
|September 22, 2025
概括
这项研究验证了MRCAT Brain软件用于仅MRI放射治疗的规划,显示了临床上可接受的剂量计准确性和精确的患者设置验证,用于治疗脑癌. 合成CT溶液可用于临床使用.
科学领域:
- 辐射疗法 辐射疗法
- 医疗成像医学成像
- 计算解剖学的计算解剖学
背景情况:
- 仅用MRI进行放射治疗规划 (RTP) 需要合成CT (sCT) 图像来准确计算剂量.
- 评估商业sCT解决方案对于大脑RTP的临床采用至关重要.
研究的目的:
- 评估MRCAT Brain商用sCT解决方案的临床可行性,用于仅用MRI进行脑辐射治疗.
- 为了评估剂量计准确性和患者设置验证,使用MRCAT Brain.
主要方法:
- 使用MRCAT Brain生成的sCT图像对93名用VMAT治疗的大脑癌症患者.
- 重新计算了sCT的临床计划,并将DVH统计数据与原始CT计划进行了比较.
- 使用70名患者和572名CBCT注册的验证患者设置准确性,比较sCT-CBCT和CT-CBCT.
主要成果:
- 规划目标体积 (PTV) 的平均剂量差异为0.4%.
- 有风险的器官 (OAR) 的平均剂量差异低于0.3%.
- 患者设置验证实现了亚毫米和亚度精度.
结论:
- 在MRCAT大脑解决方案是临床上可行的只有MRI的大脑放射治疗.
- 剂量计准确性在临床上是可以接受的,患者设置验证非常准确.
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