在间歇性肺病中Tropheryma whipplei:一个病例系列
Juan Li1, Bingpeng Guo1, Gui Zhao1
1State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Respiratory medicine case reports
|September 22, 2025
概括
在患有间歇性肺病 (ILD) 患者的肺部检测到Tropheryma whipplei (TW). 用抗生素治疗TW稳定了ILD的进展,这表明这种细菌在肺部疾病中的作用.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- (Tropheryma whipplei,TW) 与惠普尔病有关,主要影响胃肠道,心脏和眼睛.
- 新出现的证据表明,TW可能在帕伦基马肺部疾病中发挥作用.
- 现在,先进的测序技术允许在患有间歇性肺病 (ILD) 的患者的支气管洗液 (BALF) 中检测TW.
研究的目的:
- 调查Tropheryma whipplei在患有渐进性间歇性肺病的患者中的存在和影响.
- 为了评估ILD患者在确诊TW感染的情况下对抗生素治疗的治疗反应.
主要方法:
- 下一代测序 (NGS) 的BALF检测TW在三个ILD患者.
- 聚合酶链反应 (PCR) 确认TW的存在.
- 临床评估和对ILD进展和治疗反应的随访.
主要成果:
- 在三个患有进展性ILD的患者的BALF中确定了TW.
- 在用多西环素和氧化治疗后,在BALF.中无法检测到TW.
- 在3-6个月的随访期间,在所有三名患者中都观察到ILD稳定.
结论:
- 在BALF中检测到Tropheryma whipplei表明它作为致病原体的潜在作用有助于ILD进展.
- 这些发现突显了肺微生物组在ILD中的变化的重要性.
- 用抗生素向TW可能为特定的ILD病例提供治疗效益.
相关概念视频
01:29Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:28Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:26Pulmonary Tuberculosis IV
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
01:28Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
01:23Tuberculosis
Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...