患有肝硬化的成年人的多维疼痛经验:一个横截面调查研究
Franklin F F Gorospe1,2,3, David Wong4, Elizabeth Lee4
1Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.
Gastro hep advances
|September 22, 2025
概括
肝硬化患者经历中度疼痛和活动干扰. 肝脏疾病的严重程度,,与疼痛强度有显著的相关性,突出了针对性管理策略的需要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 疼痛医学 医学 疼痛医学
- 临床研究 临床研究
背景情况:
- 患有肝脏疾病,特别是肝硬化症的患者经常报告未缓解的疼痛.
- 了解疼痛的多维性质对于在肝硬化中管理疼痛的负担至关重要.
- 这项研究研究了生物心理社会疼痛因素及其与肝病严重程度的关系.
研究的目的:
- 探索导致肝硬化患者疼痛的生物心理社会因素.
- 为了检查疼痛强度和肝病严重程度之间的关联,按末期肝病模型 (MELD-Na) 评分进行测量.
- 在这个人群中评估疼痛特征,自我护理管理和疼痛干扰.
主要方法:
- 在2021年,加拿大 ambulatory hepatology 诊所采用了一种横截面调查设计.
- 包括118名具有记录MELD-Na得分的参与者.
- 使用简要疼痛清单评估疼痛特征,自我护理和干扰;多重线性回归分析了MELD-Na和疼痛强度关系.
主要成果:
- 平均复合疼痛强度得分为4 ± 2.4.4. 常见的疼痛部位包括腹部 (83.1%),下腿 (59.3%) 和下背部 (56.8%).
- 疼痛干扰得分对一般活动 (5.8 ± 3.1),行走能力 (5.7 ± 3.3) 和睡眠 (5.6 ± 3.6) 有意义.
- 疼痛强度与肝脏疾病的严重程度有关 (MELD-Na评分:23-31β=0.43,21-22β=0.28,17-20β=0.19) 和身体因素,如 (β=0.16) 和 (β=0.28).
结论:
- 中度疼痛和与疼痛相关的活动干扰在肝硬化成年人中很普遍.
- ,和整体肝病严重程度是疼痛强度的重要预测因素.
- 对这种患者群体,对生物心理社会疼痛管理干预措施的进一步研究是有必要的.
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