在怀孕前和怀孕期间接种COVID-19疫苗后,早产的风险
M de Feijter1, L C M Vissers1, L Davidson1
1Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, Netherlands.
Frontiers in drug safety and regulation
|September 22, 2025
概括
在怀孕期间接种COVID-19疫苗是安全的,不会增加早产 (PL) 的风险. 这项研究发现疫苗接种和PL之间没有关联,支持其对孕妇的安全性.
科学领域:
- 产科和妇科 产科和妇科
- 传染病和流行病学 传染病和流行病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 孕妇面临SARS-CoV-2感染的更高风险,包括严重疾病和不良结果.
- 接种COVID-19疫苗有效预防严重感染.
- 需要进行观察性研究来确认怀孕期间COVID-19疫苗接种的安全性.
研究的目的:
- 为了确定怀孕期间的COVID-19疫苗接种是否与早产 (PL) 的风险增加有关.
- 评估COVID-19疫苗在孕妇群体中的安全性.
主要方法:
- 一项前性队列研究,涉及2021年2月至2022年8月期间注册的5910名孕妇.
- 关于COVID-19疫苗接种,PL和混因子的数据是通过网络问卷自我报告的.
- 使用随时间变化的生存分析来估计PL的危险比率 (HR).
主要成果:
- 88%的参与者在怀孕期间至少接种了一次COVID-19疫苗.
- 在怀孕期间 (aHR=0.93) 或怀孕前 (aHR=1.09) 接种COVID-19疫苗和PL风险之间没有发现统计学上显著的关联.
- 怀孕任何三个月的COVID-19疫苗接种与PL的风险没有关联.
结论:
- 在怀孕前或怀孕期间接种的COVID-19疫苗与早产风险的增加无关.
- 这些发现有助于支持孕妇COVID-19疫苗接种安全性的证据.
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