对长非编码RNA母性表达基因3多态和癌症易感性之间的关联进行元分析
Yuan-Yuan Hu1,2, Rui Chen2, Xue-Feng Li3
1Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, P.R. China.
Oncology letters
|September 22, 2025
概括
孕产妇表达的3基因 (MEG3) rs7158663 G>A多态性与癌症风险增加有关. 这一元分析证实了MEG3多态性作为癌症发展的潜在风险因素.
科学领域:
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 长非编码RNAs (lncRNAs) 在基因调节中起着至关重要的作用.
- 母性表达基因3 (MEG3) 是一种涉及各种生物过程的lncRNA,包括癌症.
- 之前关于MEG3多态和癌症风险之间的关联的研究已经产生了不一致的结果.
研究的目的:
- 进行全面的元分析,调查MEG3基因多态和癌症风险之间的关联.
- 巩固现有病例控制研究的证据,以提供更可靠的评估.
- 确定可能导致癌症易感性的特定MEG3变异.
主要方法:
- 在线数据库的系统文献搜索到2024年12月.
- 包括24篇出版物与45个独立的病例控制研究.
- 在各种遗传模型下使用几率比率 (OR) 和95%置信区间 (CI) 的统计分析,以及异质性和偏差评估.
主要成果:
- MEG3 rs7158663 G>A多态 (A等位基因) 与癌症风险增加有显著关联 (OR,1.34;95% CI,1.14-1.56).
- 这种关联在各个子组中保持一致,包括哈迪-韦恩伯格平衡状态和族群 (东亚,中东).
- MEG3 rs11160608 A>C多态性显示出与癌症风险的显著关联,特别是在东亚人群中.
结论:
- MEG3 rs7158663 G>A多态性被确定为癌症发展的潜在风险因素.
- MEG3基因变异,特别是rs7158663,需要进一步研究癌症病因.
- 这些发现有助于理解与lncRNAs相关的癌症易感性的遗传基础.
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