间接胆红素与糖尿病视网膜病变风险相反,是潜在的预测生物标志物
Xiao-Ying Lin1, Yi-Xuan Zheng1, Meng-Meng Liu2
1Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
World journal of diabetes
|September 22, 2025
概括
间接胆红素 (IBIL) 可能成为预测2型糖尿病患者糖尿病视网膜病变 (DR) 风险的新生物标志物. 较高的IBIL水平与发展DR的风险降低有关.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
- 目前用于DR预测的生物标志物不足.
- 早期发现DR风险对于干预至关重要.
研究的目的:
- 确定一种用于预测2型糖尿病患者DR风险的新生物标志物.
- 调查 bilirubin 水平与 DR 发育之间的关联.
- 评估间接 bilirubin (IBIL) 作为预测标记物的潜力.
主要方法:
- 对6993名住院T2DM患者 (2013-2020) 的横截面研究.
- 患者分为DR和非DR组.
- 统计分析包括单变量,相关性,多变量,子组和ROC曲线分析.
主要成果:
- 总胆红素,间接胆红素 (IBIL) 和直接胆红素与DR风险呈负相关性 (P < 0.001).
- 较高的IBIL水平独立地与较低的DR风险相关 (OR = 0.500,P < 0.001).
- IBIL水平与EGFR和白蛋白/肌素比率等指标呈正相关性.
结论:
- 作为一种非侵入性,具有成本效益的生物标志物,IBIL显示出预测T2DM中DR风险的前景.
- 高风险患者的早期鉴定可能会通过IBIL测量来促进.
- 需要进一步的多中心纵向研究来验证这些发现并探索机制.
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