CYP2C8-介导的药物相互作用和影响相互作用幅度的因素
Ling-Ling Zhu1, Ling-Yan Yu2, Yan-Hong Wang2
1VIP Care and Geriatric Ward, Division of Nursing, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Drug design, development and therapy
|September 22, 2025
概括
细胞染色体P450 (CYP) 2C8是药物代谢的重要酶,但其药物相互作用 (DDI) 经常被忽视. 本综述详细介绍了CYP2C8基质,抑制剂,诱导剂和影响DDI大小的因素,这对于老年人安全使用药物至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物新陈代谢 药物新陈代谢
- 临床药房 临床药房
背景情况:
- 老年人经常有多种健康状况,导致多药.
- 细胞染色体P450 (CYP) 2C8在许多药物的代谢中发挥着关键作用.
- 与主要CYP酶相比,与CYP2C8相关的药物相互作用 (DDI) 在临床上较少被认可.
研究的目的:
- 审查由CYP2C8介导的DDI.
- 要总结影响这些相互作用的大小的因素.
- 提高对CYP2C8DDI的临床认识,以便在老年人中更安全地治疗药物.
主要方法:
- 在PubMed,Web of Science和Embase进行文献搜索,截至2025年1月.
- 搜索术语包括CYP2C8和药物相互作用.
- 研究选择遵循PRISMA指南,57项研究符合纳入标准.
主要成果:
- 确定了5种CYP2C8诱导剂,53种抑制剂和32种基质.
- 通过 in vitro-in vivo 推断,图示了典型的DDI.
- 详细介绍了影响DDI大小的众多因素,包括遗传多态,器官功能和药物特性.
结论:
- CYP2C8是一种重要的但被低估的药物代谢酶 (DME).
- 本综述提供了关于CYP2C8基质,事者,DDI和影响因素的全面摘要.
- 识别这些相互作用对于改善老年人药物安全至关重要.
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