暴露和肥胖的DNA甲基化特征
Natália Yumi Noronha1,2, Guilherme da Silva Rodrigues1, Lígia Moriguchi Watanabe3
1Department of Internal Medicine, Ribeirão Preto Medical School, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Environmental epigenetics
|September 22, 2025
概括
环境污染,特别是等有毒金属,与表观遗传变化和肥胖有关. 这项研究在肥胖个体中发现了与相关的DNA甲基化差异,影响了像Wnt信号传递这样的途径.
科学领域:
- 环境表观遗传学环境表观遗传学
- 毒理学 毒理学 毒理学
- 代谢学 代谢学 代谢学
背景情况:
- 越来越多的证据将环境污染物与表观遗传改变和人类健康问题联系在一起.
- 肥胖是一种复杂的代谢状况,受各种因素的影响,包括环境暴露.
研究的目的:
- 调查有毒金属暴露,肥胖和表观遗传修饰之间的关系.
- 在肥胖和不肥胖的人群中识别特定的金属相关DNA甲基化模式.
主要方法:
- 血清金属度使用诱导合血质谱法进行测量.
- 在450k Illumina BeadChips数据上进行了表观遗传学分析.
- 单值分解和线性回归确定了金属和DNA甲基化之间的关联.
主要成果:
- 肥胖与较高的血清含量有关,而非肥胖与较高的含量有关.
- 2045个与相关的差异甲基化位置 (DMP) 在肥胖个体中被确定.
- 暴露和DMP与睡眠,吸烟,妊娠糖尿病以及包括Wnt和TNF信号传递在内的途径有关.
结论:
- 暴露与肥胖个体的特定表观遗传变化有关.
- 这些表观遗传变化可能会调解和与肥胖相关的健康状况之间的联系.
- 像ABCF1和BRCA1这样的基因显示了与和肥胖相关的显著甲基化差异.
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