可激活的伴侣疗法用于双模态成像护送的热致死驱动的协同癌症治疗
Yilin Wan1,2, Yurong Liu2, Weihua Wen2
1School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Bioactive materials
|September 22, 2025
概括
这项研究引入了一种用于伴侣治疗的新型纳米平台,集成成像和治疗,用于实时癌症监测和增强治疗. 这种方法提高了诊断准确度和治疗反应反在精准医学.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 传统的伴随诊断 (CDx) 缺乏对癌症进展和治疗反应的实时监测能力.
- 精准医学需要先进的工具来进行准确的诊断和动态的治疗反.
研究的目的:
- 开发一个基于双模态成像的伴侣治疗学 (CTx) 纳米平台,用于增强癌症诊断和实时治疗反.
- 将可激活的光声学 (PA) 和光 (FL) 成像与协同光热/饥饿疗法相结合.
主要方法:
- 将葡萄糖氧化酶 (GOx) 组装成一个可pH激活近红外 (NIR) 染料 (LET-Cl) 的纳米平台 (LET-Cl@GOx).
- 利用酸性瘤微环境 (TME) 激活PA/FL成像用于监测GOx催化.
- 实施级联增强的光热/饥饿疗法,使用三重闭环反系统.
主要成果:
- 该LET-Cl@GOx纳米平台能够在酸性TME中启动PA/FL成像,为TME酸化和GOx进展提供实时反.
- 通过GOx介导的瘤饥饿降低了ATP水平,提高了对光热疗法 (PTT) 的敏感性.
- 光热效应相互增强了GOx活性,创建了一个通过Caspase-3/gasdermin E通路触发 pyroptosis的积极反循环,显示出显著的体内瘤疗效.
结论:
- 开发的CTx纳米平台为精密癌症医学提供了增强的诊断准确性和实时治疗反.
- 由闭环反系统驱动的协同疗法在体内表现出了显著的瘤治疗疗效.
- 这种方法代表了用于癌症治疗的纳米医学的重大进步.
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