非侵入性耳部刺激与降低血压之间的关联:系统性审查和元分析
Michiaki Nagai1,2, Karl-Philipp Rommel3, Yukiko Nakano4
1Cardiovascular Section, Department of Medicine, University of Oklahoma, Health Science Center, Andrews Academic Tower, Suite 5400, Oklahoma City, OK 73104, USA.
非侵入性耳部刺激显著降低血压 (BP) 和心率 (HR). 这种增强迷走神经活动的方法提供了一种安全的方法,尽管对高血压治疗需要进一步的研究.
科学领域:
- 心血管生理学心血管生理学
- 综合医学是一个整体的医学.
- 神经调节是一种神经调节.
背景情况:
- 对于高血压的耳部刺激的临床试验显示不清楚的结果.
- 非侵入性耳部刺激对心血管血液动力学的影响需要进一步调查.
研究的目的:
- 系统地审查和元分析非侵入性耳部刺激对血压 (BP) 和心率 (HR) 的影响.
- 评估非侵入性耳部刺激对心血管调节的安全性和潜力.
主要方法:
- 随机对照试验的系统审查和元分析.
- 在PubMed,ICHUSHI和Cochrane中央图书馆搜索了英语研究.
- 分析了18项关于耳朵电刺激和针压力的研究 (n=959) 的数据.
主要成果:
- 系统血压 (WMD -4.435 mmHg) 和透气血压 (WMD -2.212 mmHg) 的显著降低.
- 心率显著降低 (大规模杀伤器 -3.069次/分钟).
- 没有报告严重不良事件;高异质性可能是由于刺激持续时间和基线值.
结论:
- 非侵入性耳部刺激可以通过增强迷走神经活动来安全地降低血压和HR.
- 需要进一步的研究,以确定非侵入性耳部刺激作为最终的高血压治疗方法.
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