布尔网络在噪声下的吸引力稳定性
Byungjoon Min1,2,3, Jeehye Choi2, Reinhard Laubenbacher3
1Department of Physics, Chungbuk National University, Cheongju, Chungbuk 28644, Korea.
ArXiv
|September 22, 2025
概括
噪音会影响布尔网络的稳定性. 过渡动态,而不仅仅是盆地大小,决定了在局部噪音下的吸引力主导地位,揭示了对复杂系统行为的关键见解.
科学领域:
- 系统生物学 系统生物学
- 计算生物学 计算生物学
- 理论神经科学 理论神经科学
背景情况:
- 布尔网络被广泛用于模拟复杂的生物系统.
- 了解吸引力动态和稳定性对于预测系统行为至关重要.
- 噪音是生物系统中固有的因素,可以显著改变动态.
研究的目的:
- 调查噪声对布尔网络中吸引子稳定性和过渡行为的影响.
- 开发一个定量框架来评估在噪音条件下的吸引力稳定性和主导地位.
- 区分局部与全球噪声对网络动态的影响.
主要方法:
- 使用单节点扰动构建吸引子矩阵.
- 基于动态结构的吸引器稳定性的量化.
- 在局部和全球干扰下分析噪音诱导的过渡模式.
主要成果:
- 吸引子表现出比单靠盆地大小预测的更大的稳定性.
- 全球干扰受盆地大小的影响,而局部噪音效应则由过渡模式主导.
- 噪声诱导的过渡动态提供了一个有效的和定量的吸引力稳定性的衡量.
结论:
- 动态结构在杂的布尔网络中的吸引器稳定性中起着至关重要的作用.
- 过渡动态提供了一个更准确的描述吸引力在随机扰动下的行为.
- 拟议的框架提供了一种新的方法,以了解在噪声存在时的复杂系统动态.
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