关于肝癌治疗方法的系统审查的方法质量:一个横截面研究
Billy Z Z Cheng1, Betty H Wang2, Claire Chenwen Zhong2
1Department of Administration, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Journal of hepatocellular carcinoma
|September 22, 2025
概括
对肝癌治疗方法的系统审查表明方法质量不佳,其中90.8%被评为非常低. 改善审查协议和报告对于癌症研究中可靠的证据至关重要.
科学领域:
- 在瘤学瘤学.
- 基于证据的医学基于证据的医学.
- 研究方法研究方法研究方法学
背景情况:
- 系统性审查 (SRs) 对于评估治疗有效性至关重要.
- 特别报告中的方法缺陷可能会损害其发现的可靠性和有效性.
- 高质量的SRs对于癌症治疗中的知情临床决策至关重要.
研究的目的:
- 评估以肝癌治疗为重点的系统审查的方法质量.
- 确定影响这些系统性审查质量的因素.
- 为提高未来肝癌SRs可靠性提供建议.
主要方法:
- 一项横截面研究分析了2014年1月至2023年10月期间发表的119篇关于肝癌治疗的系统评论.
- 评估系统性审查的方法质量2 (AMSTAR 2) 工具被用于质量评估.
- 多变量回归分析确定了与方法质量相关的因素.
主要成果:
- 显著的大多数SR (90.8%) 被评为质量极低.
- 只有一个SR (0.8%) 实现了高整体质量.
- 与更高质量积极相关的因素包括最近出版日期,更高的期刊影响因素和欧洲对应作者.
结论:
- 关于肝癌治疗的系统审查的方法质量目前不令人满意.
- 作者应该优先注册协议,详细说明研究选择,采用全面的搜索策略,并报告资金来源.
- 提高SR方法对于推进基于证据的瘤学和改善患者的治疗结果至关重要.
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