脂质参数及其与2型糖尿病患者肝功能测试变量的相关性
Sai Venkatram Reddy Molugu1, Chaitra Reddy Molugu2, Hemanth Reddy Molugu3
1Medicine, Osmania Medical College, Hyderabad, IND.
Cureus
|September 22, 2025
概括
肝酶升高和脂质异常常见于2型糖尿病 (T2DM). 监测脂质概况对于预防并发症和管理糖尿病患者肝脏健康至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 临床生物化学 临床生物化学
背景情况:
- 2型糖尿病 (T2DM) 经常与代谢障碍有关.
- 肝功能异常和脂质失调是T2DM患者常见的并发症.
- 了解肝酶和脂质配置文件之间的相关性对于风险分层和管理至关重要.
研究的目的:
- 为了确定T2DM患者肝酶升高和脂质特征异常的患病率.
- 为了研究肝功能测试和脂质参数之间的关联,在这个人群中.
- 探索肝酶对非酒精性脂肪性肝病 (NAFLD) 等疾病的预测价值.
主要方法:
- 研究了130名T2DM患者的队列.
- 血清样本被分析为肝功能测试和脂质资料.
- 使用后勤回归和ROC曲线分析来评估相关性和预测值.
主要成果:
- 在30.77%的T2DM患者中发现肝酶升高,在70.76%的T2DM患者中发现脂质异常.
- 酸氨基转移酶 (AST) 和氨基转移酶 (ALT) 与各种脂质参数有显著的相关性.
- 异常的总胆固醇,LDL和甘油三都与T2DM独立相关;ALT显示AUROC为0.86用于预测NAFLD.
结论:
- 肝功能异常和脂质失调在T2DM患者中经常同时存在,这表明需要综合监测.
- 持续监测脂质样本可能有助于预防心血管并发症.
- 对于糖尿病患者的肝酶升高,建议定期对代谢功能障碍相关的脂肪性肝病 (MASLD) 进行查,并对晚期肝脏进行后续评估.
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